©2009-2019 by Wyoming Sky Goldens

last updated 10.19.2019

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** All the information on this page was gathered from 

Paw Prints Genetics

unless cited otherwise.

 

 

 

Genetic Disease Testing

It is very important to test for genetic diseases that can potentially be present in Golden Retrievers. We use animalgenetics.com to test our golden retrievers. We use the golden retriever panel which includes:

 

(click on each name to learn more about them)

Degenerative Myelopathy 

Aliases: Canine degenerative myelopathy, DM

Ichthyosis (Golden Retriever Type) 

Progressive Retinal Atrophy, Golden Retriever 1 

Aliases: GR-PRA1, GR1-PRA

Progressive Retinal Atrophy, Golden Retriever 2

Aliases: GR-PRA2, GR2-PRA

Progressive Retinal Atrophy, Progressive Rod-Cone Degeneration

Aliases: PRA-PRCD, PRCD

Neuronal ceroid-lipofuscinoses

Aliases: NCLs

Genetic Results

Results for genetic testing can come back with three results:

(http://journals.plos.org/plosgenetics/article/file?type=supplementary&id=info:doi/10.1371/journal.pgen.1004635.s001)

 

-Clear (n/n)- A clear dog means that a dog does not carry the disease that it was tested for. Instead, it carries two copies of the normal gene.

 

-Carrier (n/d) - A carrier dog means that it carries one copy of the normal gene and one copy of the mutated gene that was tested for. Carriers will pass down the gene to 50% of their offspring. 

 

-Affected (d/d) - An affected dog means that is carries two copies of the mutated gene that it was tested for and it does not carry the normal gene. Affected dogs will pass down one copy to all of their offspring. 

 

Examples:

 

* Clear (N/N) x Clear (N/N) = 100% Clear (N/N)

* Clear (N/N) x Carrier (D/N) = 50% Clear (N/N), 50% Carrier (D/N) (This is an average, individual litters may see anywhere from 100% Clear to 100% Carrier)

* Clear (N/N) x Affected (D/D) = 100% Carrier (D/N)

* Carrier (D/N) x Carrier (D/N) = 25% Clear (N/N), 50% Carrier (D/N), 25% Affected (D/D) (This is an average, individual litters may see more or less of any result)

* Carrier (D/N) x Affected (D/D) = 50% Carrier (D/N), 50% Affected (D/D) (This is an average, individual litters may see anything from 100% Carrier to 100% Affected)

* Affected (D/D) x Affected (D/D) = 100% Affected (D/D)